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Both of these work pretty well, the clinique spot treatment is a little stronger and more drying. These spot treatments are great if you have a couple acne on your face that are inflamed while the rest of your face is fine. I wouldn`t use this more than a couple times a week though and the best time to use it is after you clean your face and use toner. Then you apply it and avoid putting moisturizer in that area. I use these a night only when necessary. This is my photo.